"cardiomyocyte; chaperone; endoplasmic reticulum stress (ER stress); heart function; ischemia; ischemia/reperfusion; mesencephalic astrocyte-derived neurotrophic factor (MANF); protein folding; reductive stress; unfolded protein response"

Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response sensor and effector, activated transcription factor 6$α$ (ATF6). …