"ATF6; cardiac myocyte; catalase; endoplasmic reticulum stress; ischemia; ischemia/reperfusion injury; oxidative stress; protein folding; unfolded protein response"

ATF6 decreases myocardial ischemia/reperfusion damage and links ER stress and oxidative stress signaling pathways in the heart

RATIONALE: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes. Myocardial ischemia …